Role of major histocompatibility complex class II in the development of autoimmune type 1 diabetes and thyroiditis in rats

@inproceedings{Yokoi2012RoleOM,
  title={Role of major histocompatibility complex class II in the development of autoimmune type 1 diabetes and thyroiditis in rats},
  author={Norihide Yokoi and Satoshi Hidaka and Sawa Tanabe and Mihoko Ohya and Masahiro Ishima and Yumie Takagi and Norio Masui and Shizuka Seino},
  booktitle={Genes and Immunity},
  year={2012}
}
Although the MHC class II ‘u’ haplotype is strongly associated with type 1 diabetes (T1D) in rats, the role of MHC class II in the development of tissue-specific autoimmune diseases including T1D and autoimmune thyroiditis remains unclear. To clarify this, we produced a congenic strain carrying MHC class II ‘a’ and ‘u’ haplotypes on the Komeda diabetes-prone (KDP) genetic background. The u/u homozygous animals developed T1D similar to the original KDP rat; a/u heterozygous animals did develop… CONTINUE READING
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