Role of magnesium ion in mithramycin-DNA interaction: binding of mithramycin-Mg2+ complexes with DNA.

@article{Aich1995RoleOM,
  title={Role of magnesium ion in mithramycin-DNA interaction: binding of mithramycin-Mg2+ complexes with DNA.},
  author={P. Aich and D. Dasgupta},
  journal={Biochemistry},
  year={1995},
  volume={34 4},
  pages={
          1376-85
        }
}
  • P. Aich, D. Dasgupta
  • Published 1995
  • Chemistry, Medicine
  • Biochemistry
  • Mithramycin is an anticancer drug that blocks macromolecular synthesis via reversible interaction with the DNA template in the presence of bivalent metal ions such as Mg2+. The role of Mg2+ in this antibiotic-DNA interaction is not clear. We approached the problem in two steps via studies on the interactions between (i) mithramycin and Mg2+ and (ii) mithramycin-Mg2+ complex(es) and DNA. Spectroscopic techniques such as absorption, fluorescence, and CD were employed for the purpose. From… CONTINUE READING
    Structure and function of “metalloantibiotics”
    • 181
    • PDF
    Inhibition of p53-mediated transcriptional responses by mithramycin A
    • 72
    • PDF
    Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences
    • 43
    • Highly Influenced
    • PDF