Role of macula densa adenosine triphosphate (ATP) in tubuloglomerular feedback.

@article{Ren2004RoleOM,
  title={Role of macula densa adenosine triphosphate (ATP) in tubuloglomerular feedback.},
  author={Yilin Ren and Jeffrey L. Garvin and Ruisheng Liu and Oscar A. Carretero},
  journal={Kidney international},
  year={2004},
  volume={66 4},
  pages={1479-85}
}
BACKGROUND Recent studies have shown that adenosine triphosphate (ATP) is liberated from macula densa cells in response to increased tubular NaCl in vitro. We tested the hypothesis that increased NaCl in the macula densa stimulates the release of ATP, resulting in extracellular formation of adenosine which is involved in signal transmission of the tubuloglomerular feedback response. METHODS Rabbit afferent arterioles and attached macula densas were simultaneously microperfused in vitro… CONTINUE READING

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