Role of macrophages in the development of arteritis in MRL strains of mice with a deficit in Fas-mediated apoptosis.

Abstract

The lpr and gld genes have been shown to encode the Fas antigen deletion mutant and the Fas ligand (FasL) mutant, respectively. An MRL strain of mice bearing the gld gene was observed to spontaneously develop granulomatous arteritis, similar to that in mice bearing the lpr gene, indicating that arteritis in this strain is due to an inefficient Fas-FasL… (More)

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@article{Taniguchi1996RoleOM, title={Role of macrophages in the development of arteritis in MRL strains of mice with a deficit in Fas-mediated apoptosis.}, author={Yasunori Taniguchi and M. R. Ito and Shigemi Mori and Sanae Yonehara and Masato Nose}, journal={Clinical and experimental immunology}, year={1996}, volume={106 1}, pages={26-34} }