Role of macrophages in infection with Rickettsia conorii.

Macrophages obtained from the abdominal cavities and spleens of DBA/2 mice and guinea pigs convalescent after Rickettsia conorii infection digested the rickettsiae in vitro more actively than those from uninfected animals. The activation of macrophages was manifested by their capacity to inhibit replication of the rickettsiae and to digest them as well as… CONTINUE READING