Role of macrophages in defective cell mediated immunity in lepromatous leprosy. II. Macrophage and lymphocyte interaction.

@article{Birdi1980RoleOM,
  title={Role of macrophages in defective cell mediated immunity in lepromatous leprosy. II. Macrophage and lymphocyte interaction.},
  author={Tannaz J. Birdi and P R Salgame and Pathmathevan Mahadevan and Noshir Hormusji Antia},
  journal={International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association},
  year={1980},
  volume={48 2},
  pages={178-82}
}
Macrophages from lepromatous patients after phagocytosis of M. leprae showed alteration in their surface property as determined by their ability to express Fc receptors. The same macrophages without intracellular M. leprae show normal Fc receptors. The lepromatous macrophages also show very poor interaction with lymphocytes in the presence of M. leprae while they are able to interact with lymphocytes when exposed to other antigens. These observations along with earlier ones on macrophage… CONTINUE READING

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