Role of macrophages in bile acid-induced inflammatory response of fetal lung during maternal cholestasis

@article{Herraez2013RoleOM,
  title={Role of macrophages in bile acid-induced inflammatory response of fetal lung during maternal cholestasis},
  author={Elisa Herraez and E. Corral Lozano and Evelyn Poli and Verena Keitel and Daniele De Luca and Catherine Williamson and Jose J. G. Marin and Rocio I R Macias},
  journal={Journal of Molecular Medicine},
  year={2013},
  volume={92},
  pages={359-372}
}
Infant respiratory distress syndrome (iRDS) in babies born from women with intrahepatic cholestasis of pregnancy (ICP) has been associated with intrauterine exposure to high bile acid levels. Here, we have investigated the role of macrophages in hypercholanemia-induced changes in maternal and fetal lung. Obstructive cholestasis in pregnant rats (OCP) was maintained from day 14 of gestation to term. Gene expression was determined by RT-QPCR, Western blot, and immunofluorescence. The maternal… CONTINUE READING
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