Role of macrophages and macrophage-derived cytokines in the pathogenesis of Kilham rat virus-induced autoimmune diabetes in diabetes-resistant BioBreeding rats.

@article{Chung1997RoleOM,
  title={Role of macrophages and macrophage-derived cytokines in the pathogenesis of Kilham rat virus-induced autoimmune diabetes in diabetes-resistant BioBreeding rats.},
  author={Yoon Chung and Hee-Sook Jun and Y Kang and Kensuke Hirasawa and Byoung Rai Lee and Nico Van Rooijen and J. W. Yoon},
  journal={Journal of immunology},
  year={1997},
  volume={159 1},
  pages={466-71}
}
The diabetes-resistant BioBreeding (DR-BB) rat, derived from diabetes-prone forebears, does not normally develop spontaneous insulitis or diabetes, but when infected with Kilham rat virus (KRV) this animal develops autoimmune diabetes similar to the diabetes-prone BioBreeding (DP-BB) rat. In this study, we attempted to determine whether macrophages and macrophage-derived cytokines play a role in the development of KRV-induced diabetes in DR-BB rats. Seventy-eight percent of DR-BB rats treated… CONTINUE READING