Role of macrophage scavenger receptors in response to Listeria monocytogenes infection in mice.

@article{Ishiguro2001RoleOM,
  title={Role of macrophage scavenger receptors in response to Listeria monocytogenes infection in mice.},
  author={Taketo Ishiguro and Makoto Naito and Takashi Yamamoto and Go Hasegawa and Fumitake Gejyo and Masao Mitsuyama and Hanako Suzuki and Tatsuhiko Kodama},
  journal={The American journal of pathology},
  year={2001},
  volume={158 1},
  pages={179-88}
}
Type I and type II macrophage scavenger receptors (SR-A I/II) recognize a variety of polyanions including bacterial cell-wall products such as lipopolysaccharide, suggesting a role for SR-A I/II in immunity against bacterial infection. SR-A I/II-deficient (MSR-A-/-) mice were more susceptible to infection with listeriolysin-O (LLO)-producing Listeria monocytogenes. After infection, Kupffer cells in wild-type (MSR-A+/+) mice phagocytized larger numbers of Listeria than those in MSR-A-/- mice… CONTINUE READING
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