Role of mTOR in neuroprotection and axon regeneration after inflammatory stimulation

  title={Role of mTOR in neuroprotection and axon regeneration after inflammatory stimulation},
  author={Marco Leibinger and Anastasia Andreadaki and Dietmar Fischer},
  journal={Neurobiology of Disease},
Mature retinal ganglion cells (RGCs) do not normally regenerate injured axons, but degenerate after axotomy. However, inflammatory stimulation (IS) enables RGCs to survive axotomy and regenerate axons in the injured optic nerve. Similar effects are achieved by the genetic deletion of phosphatase and tensin homolog (PTEN) and subsequent mammalian target of rapamycin (mTOR) activation. Here, we report that IS prevents the axotomy-induced decrease of mTOR activity in RGCs in a CNTF/LIF-dependent… CONTINUE READING


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