Role of mRNA expression of transcription factors in glucocorticoid sensitivity of peripheral blood mononuclear cells and disease state in rheumatoid arthritis.

@article{Onda2004RoleOM,
  title={Role of mRNA expression of transcription factors in glucocorticoid sensitivity of peripheral blood mononuclear cells and disease state in rheumatoid arthritis.},
  author={Kenji Onda and Emiko Rimbara and Toshihiko Hirano and Kitaro Oka and Haruo Abe and Koichiro Tahara and Hirofumi Takanashi and Norioki Tsuboi and Tomoyuki Niitsuma and Tohru Hayashi},
  journal={The Journal of rheumatology},
  year={2004},
  volume={31 3},
  pages={464-9}
}
OBJECTIVE To investigate the mechanisms underlying glucocorticoid (GC) resistance in rheumatoid arthritis (RA), we evaluated the suppressive effects of prednisolone (PSL) or methylprednisolone (MPSL) on the blastogenesis of peripheral blood mononuclear cells (PBMC). We also measured the expression of mRNA for transcription factors [GC receptor-alpha (GRalpha) and activator protein-1] known to be involved in the exertion of GC effects. METHODS Twenty-six patients with RA and 17 healthy… CONTINUE READING