Role of lysophospholipid growth factors in the modulation of aqueous humor outflow facility.

@article{Mettu2004RoleOL,
  title={Role of lysophospholipid growth factors in the modulation of aqueous humor outflow facility.},
  author={Priyatham S. Mettu and P Deng and Uma Kant Misra and Govind Gawdi and David Lee Epstein and Ponugoti Vasantha Rao},
  journal={Investigative ophthalmology & visual science},
  year={2004},
  volume={45 7},
  pages={2263-71}
}
PURPOSE To investigate the role of lysophospholipid growth factors in the regulation of aqueous humor outflow in the trabecular meshwork (TM). METHODS The expression profile of the endothelial differentiation gene (Edg) family of G-protein coupled receptors was determined by RT-PCR of human TM (HTM) cell-derived total RNA and by PCR amplification of HTM cell-derived and tissue-derived cDNA libraries. The effects of lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) on actin… CONTINUE READING
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