Role of lysines in mediating interaction of modified low density lipoproteins with the scavenger receptor of human monocyte macrophages.

Abstract

The ability of the scavenger receptor of human monocyte macrophages to recognize human low density lipoproteins (LDL) progressively modified by three lysine-specific reagents, malondialdehyde, acetic anhydride, or succinic anhydride, has been investigated. Regardless of the reagent utilized, receptor-mediated uptake was dependent upon modification of… (More)

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