Role of lymphoid chemokines in the development of functional ectopic lymphoid structures in rheumatic autoimmune diseases.

@article{Corsiero2012RoleOL,
  title={Role of lymphoid chemokines in the development of functional ectopic lymphoid structures in rheumatic autoimmune diseases.},
  author={Elisa Corsiero and Michele Bombardieri and Antonio Manzo and Serena Bugatti and Mariagrazia Uguccioni and Costantino Pitzalis},
  journal={Immunology letters},
  year={2012},
  volume={145 1-2},
  pages={62-7}
}
A sizeable subset of patients with the two most common organ-specific rheumatic autoimmune diseases, rheumatoid arthritis (RA) and Sjögren's syndrome (SS) develop ectopic lymphoid structures (ELS) in the synovial tissue and salivary glands, respectively. These structures are characterized by perivascular (RA) and periductal (SS) clusters of T and B lymphocytes, differentiation of high endothelial venules and networks of stromal follicular dendritic cells (FDC). Accumulated evidence from other… CONTINUE READING