Role of low CD4 levels in the influence of human immunodeficiency virus type 1 envelope V1 and V2 regions on entry and spread in macrophages.

@article{Walter2005RoleOL,
  title={Role of low CD4 levels in the influence of human immunodeficiency virus type 1 envelope V1 and V2 regions on entry and spread in macrophages.},
  author={Brandon L Walter and Kathy Wehrly and R. Swanstrom and Emily J Platt and David Kabat and Bruce Chesebro},
  journal={Journal of virology},
  year={2005},
  volume={79 8},
  pages={4828-37}
}
Human immunodeficiency virus type 1 (HIV-1) isolates vary in their ability to infect macrophages. Previous experiments have mapped viral determinants of macrophage infectivity to the V3 hypervariable region of the HIV-1 envelope glycoprotein. In our earlier studies, V1 and V2 sequences of HIV-1 were also shown to alter the ability of virus to spread in macrophage cultures, whereas no effect was seen in lymphocyte cultures. In the present study, determinants that allowed certain HIV-1 clones to… CONTINUE READING
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