Role of lipoproteins in the plasma binding of SDZ PSC 833, a novel multidrug resistance-reversing cyclosporin.

@article{Simon1998RoleOL,
  title={Role of lipoproteins in the plasma binding of SDZ PSC 833, a novel multidrug resistance-reversing cyclosporin.},
  author={Nicolas Simon and {\'E}ric Dailly and Olivier Combes and E. Malaurie and Michel Lemaire and Jean Paul Tillement and Sa{\"i}k Urien},
  journal={British journal of clinical pharmacology},
  year={1998},
  volume={45 2},
  pages={173-5}
}
AIMS The plasma binding of the cyclosporin D analogue SDZ PSC 833 was investigated in vitro. METHODS The plasma total binding constant (corresponding to the bound-to-free concentration or binding ratio) was determined at 37 degrees C by the erythrocyte partitioning technique on plasma samples from three healthy volunteers and three cancer patients. Lipoproteins were also removed from plasma samples from three healthy volunteers by a standard ultracentrifugal technique. RESULTS SDZ PSC 833… CONTINUE READING