Role of lipoprotein-associated lysophospholipids in migratory activity of coronary artery smooth muscle cells.

@article{Damirin2007RoleOL,
  title={Role of lipoprotein-associated lysophospholipids in migratory activity of coronary artery smooth muscle cells.},
  author={Alatangaole Damirin and Hideaki Tomura and Mayumi Komachi and Jin-Peng Liu and Chihiro Mogi and Masayuki Tobo and Jinghong Wang and Toshinori Kimura and Atsushi Kuwabara and Yuji Yamazaki and Hideo Ohta and Doon-Soon Im and Koichi Sato and Fumikazu Okajima},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={292 5},
  pages={
          H2513-22
        }
}
The migration of vascular smooth muscle cells (SMCs) is a hallmark of the pathogenesis of atherosclerosis and restenosis after angioplasty. Plasma low-density lipoprotein (LDL), but not high-density lipoprotein (HDL), induced the migration of human coronary artery SMCs (CASMCs). Among bioactive lipids postulated to be present in LDL, lysophosphatidic acid (LPA) appreciably mimicked the LDL action. In fact, the LDL-induced migration was markedly inhibited by pertussis toxin, an LPA receptor… CONTINUE READING

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