Role of lipocortin-1 in the anti-hyperalgesic actions of dexamethasone.

@article{Ferreira1997RoleOL,
  title={Role of lipocortin-1 in the anti-hyperalgesic actions of dexamethasone.},
  author={S{\'e}rgio Henrique Ferreira and Fernando Q Cunha and Berenice B. Lorenzetti and M A Michelin and Mauro Perretti and Roderick John Flower and Steve Poole},
  journal={British journal of pharmacology},
  year={1997},
  volume={121 5},
  pages={
          883-8
        }
}
1. The effect of dexamethasone, lipocorton-1(2-26) and an antiserum to lipocortin-1(2-26) (LCPS1) upon the hyperalgesic activities in rats of carrageenin, bradykinin, tumour necrosis factor alpha (TNF alpha), interleukin-1(2), interleukin-6 (IL-6), interleukin-8 (IL-8), prostaglandin E beta (PGE2) and dopamine were investigated in a model of mechanical hyperalgesia. 2. Hyperalgesic responses to intraplantar (i.pl.) injections of carrageenin (100 micrograms), bradykinin (500 ng), TNF alpha (2.5… CONTINUE READING

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