Role of lipid polymorphism in G protein-membrane interactions: nonlamellar-prone phospholipids and peripheral protein binding to membranes.

@article{Escrib1997RoleOL,
  title={Role of lipid polymorphism in G protein-membrane interactions: nonlamellar-prone phospholipids and peripheral protein binding to membranes.},
  author={P. Escrib{\'a} and A. Ozaita and C. Ribas and A. Miralles and E. Fodor and T. Farkas and J. Garc{\'i}a-Sevilla},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 21},
  pages={
          11375-80
        }
}
Heterotrimeric G proteins (peripheral proteins) conduct signals from membrane receptors (integral proteins) to regulatory proteins localized to various cellular compartments. They are in excess over any G protein-coupled receptor type on the cell membrane, which is necessary for signal amplification. These facts account for the large number of G protein molecules bound to membrane lipids. Thus, the protein-lipid interactions are crucial for their cellular localization, and consequently for… Expand
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References

SHOWING 1-10 OF 31 REFERENCES
Role of membrane lipids in the interaction of daunomycin with plasma membranes from tumor cells: implications in drug-resistance phenomena.
TLDR
Equilibrium binding studies on the interaction between the anthracycline daunomycin and plasma membrane fractions from daunaomycin-sensitive and -resistant murine leukemia P-388 cells suggest that interaction of protein components with the drug should not be responsible for the observed differences in drug binding exhibited by plasma membranes from drug- sensitive and - resistant cells. Expand
Regulation of G protein-coupled receptors by receptor kinases and arrestins.
TLDR
It is found that rhodopsin kinase is predominantly expressed in the retina, where it localizes to both rod and cones by immunofluorescence, and in the pineal body to a lesser extent. Expand
Disruption of cellular signaling pathways by daunomycin through destabilization of nonlamellar membrane structures.
TLDR
An important role of the lipid component of the cell membrane in signal transduction and its alteration by anthracyclines is revealed, which could explain how anthrACYclines can exert their cytocidal action without entering the cell. Expand
Lipid Modifications of Trimeric G Proteins (*)
TLDR
This work has shown how different lipid modifications of different G protein subunits affect specific protein-protein interactions and localization to specific cellular sites and regulation of these modifications, particularly palmitoylation, can provide new ways to regulate signals transmitted by G proteins. Expand
Association of the regulatory beta-adrenergic receptor kinase with rat liver microsomal membranes.
TLDR
Data suggest that several beta ARK pools may exist inside the cell, in line with recent reports showing that proteins involved in plasma membrane signal transduction, such as heterotrimeric G proteins, are also associated with membranes of different intracellular organelles. Expand
Myristoylated alpha subunits of guanine nucleotide-binding regulatory proteins.
TLDR
Chemical analysis of lipids attached covalently to purified alpha 41 and alpha 39 from bovine brain revealed myristic acid, which may play an important role in stabilizing interactions of G proteins with phospholipid or with membrane-bound proteins. Expand
The Fluid Mosaic Model of the Structure of Cell Membranes
A fluid mosaic model is presented for the gross organization and structure of the proteins and lipids of biological membranes. The model is consistent with the restrictions imposed by thermodynamics.Expand
Myristoylation of an inhibitory GTP-binding protein alpha subunit is essential for its membrane attachment.
TLDR
The results indicate that myristoylation is critical for membrane attachment of alpha i but not alpha s subunits, and that purified beta gamma subunits promoted pertussis toxin-catalyzed ADP-ribosylation of both the normal and mutant alpha i1 subunits. Expand
Low concentrations of diacylglycerol promote the binding of apolipophorin III to a phospholipid bilayer: a surface plasmon resonance spectroscopy study.
TLDR
Data support a two-step sequential binding mechanism for binding of apoLp-III to a lipid surface, which could be a general mechanism for all exchangeable apolipoproteins. Expand
High affinity binding of beta-adrenergic receptor kinase to microsomal membranes. Modulation of the activity of bound kinase by heterotrimeric G protein activation.
TLDR
The results indicate a functional relationship betweenbeta ARK and heterotrimeric G proteins in different intracellular organelles, and suggest that additional proteins may be involved in modulating the cellular localization of the kinase through a new targeting domain of beta ARK. Expand
...
1
2
3
4
...