Role of lipid components in formation and reactivation of Mycobacterium smegmatis “nonculturable” cells

@article{Nazarova2011RoleOL,
  title={Role of lipid components in formation and reactivation of Mycobacterium smegmatis “nonculturable” cells},
  author={E. Nazarova and M. Shleeva and N. S. Morozova and Yu. K. Kudykina and G. Vostroknutova and A. O. Ruzhitsky and A. Selishcheva and G. Sorokoumova and V. Shvets and A. Kaprelyants},
  journal={Biochemistry (Moscow)},
  year={2011},
  volume={76},
  pages={636-644}
}
We have found that transition of actively dividing Mycobacterium smegmatis cells into the dormant “nonculturable” state is accompanied by increase in the protein/lipid ratio and disappearance of one of the main lipid components of the mycobacterial cells, trehalose monomycolate. In this case, oleic acid is accumulated in the culture medium due to its secretion by the mycobacterial cells. Addition of lipids of different classes to “nonculturable” M. smegmatis cells induces their resuscitation… Expand
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