Role of leukotriene B4 in the interleukin-4-induced human mononuclear phagocyte activation.

@article{Dugas1996RoleOL,
  title={Role of leukotriene B4 in the interleukin-4-induced human mononuclear phagocyte activation.},
  author={Nathalie Dugas and Bernard Dugas and J. P. Kolb and Kumiko Yamaoka and J F Delfraiss and Chantal Damais},
  journal={Immunology},
  year={1996},
  volume={88 3},
  pages={384-8}
}
Interleukin-4 (IL-4) induced a time- and dose-dependent production of leukotriene B4 (LTB4) by human resting monocytes indicating that IL-4 induced the activation of the 5-lipoxygenase pathway in resting human monocytes. Maximal effect was observed in the presence of 10 ng/ml IL-4, and in kinetics experiments LTB4 production plateaued 40 min after the onset of stimulation. When stimulated for 48 hr with IL-4, resting human monocytes expressed and released the low-affinity receptor for IgE (CD23… CONTINUE READING