Role of leptin in the neuroendocrine response to fasting

@article{Ahima1996RoleOL,
  title={Role of leptin in the neuroendocrine response to fasting},
  author={Rexford S. Ahima and Daniel Prabakaran and Christos S. Mantzoros and Daqing Qu and Bradford B. Lowell and Eleftheria Maratos-Flier and Jeffrey S. Flier},
  journal={Nature},
  year={1996},
  volume={382},
  pages={250-252}
}
A TOTAL deficiency in or resistance to the protein leptin causes severe obesity1–4. As leptin levels rise with increasing adiposity in rodents5 and man6,7, it is proposed to act as a negative feedback 'adipostatic signal' to brain centres controlling energy homeostasis, limiting obesity in times of nutritional abundance1,3. Starvation is also a threat to homeostasis that triggers adaptive responses8–12, but whether leptin plays a role in the physiology of starvation is unknown. Leptin… 
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The identification of leptin has provided a framework for studying the pathogenesis of obesity in the general population, clarified the nature of the biologic response to starvation, and helped to advance the understanding of the neural mechanisms that control feeding.
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Emerging evidence suggests that, in starvation, hypoleptinemia increases activity of the hypothalamic-pituitary-adrenal axis, promoting WAT lipolysis, increasing hepatic acetyl-CoA concentrations, and maintaining euglycemia, and a leptin-mediated glucose-fatty acid cycle appears to maintain glycemia and permit survival in starvation.
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TLDR
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    Annals of the New York Academy of Sciences
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TLDR
Accumulating evidence suggests that this hormone may serve to signal to the brain information on the critical amount of fat stores that are necessary for LHRH secretion and activation of the hypothalamic‐pituitary‐gonadal axis, which is a potentially important role during pregnancy and in the physiology of the neonate.
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TLDR
The temporal relationship between leptin and other hormones in neonatal and adult mice suggests that leptin is involved in the maturation and function of the neuroendocrine axis.
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