• Corpus ID: 11977491

Role of knot (kn) in wing patterning in Drosophila.

@article{Nestoras1997RoleOK,
  title={Role of knot (kn) in wing patterning in Drosophila.},
  author={Konstantinos Nestoras and H S Lee and J. Dawson Mohler},
  journal={Genetics},
  year={1997},
  volume={147 3},
  pages={
          1203-12
        }
}
We have undertaken a genetic analysis of new strong alleles of knot (kn). The original kn1 mutation causes an alteration of wing patterning similar to that associated with mutations of fused (fu), an apparent fusion of veins 3 and 4 in the wing. However, unlike fu, strong kn mutations do not affect embryonic segmentation and indicate that kn is not a component of a general Hh (Hedgehog)-signaling pathway. Instead we find that kn has a specific role in those cells of the wing imaginal disc that… 
Activation of knot (kn) specifies the 3-4 intervein region in the Drosophila wing.
TLDR
Hedgehog (Hh) plays an important role in Drosophila wing patterning by inducing expression of Dpp, which serves to organize the wing globally across the A-P axis through the activation of the Hh-target gene, knot (kn).
Wing patterning knot untangled
TLDR
The finding of the patterning role of knot promises to complete the puzzle of the sectorial organization of the Drosophila wing.
A Novel Interaction Between hedgehog and Notch Promotes Proliferation at the Anterior–Posterior Organizer of the Drosophila Wing
TLDR
A novel collaboration by the Hedgehog and Notch pathways that regulates proliferation in the 3–4 intervein region independently of Decapentaplegic is revealed.
hedgehog and wing development in Drosophila: a morphogen at work?
  • M. Vervoort
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2000
TLDR
The ways in which Hh forms an activity gradient to lay the basis of patterning of the adult wing are described here and provide important advances which may help in understanding the function of Hh proteins in normal and pathological development and tumourigenesis in humans.
Notch and Wingless modulate the response of cells to Hedgehog signalling in the Drosophila wing.
TLDR
Modulation of the response of cells to Hh along the future proximodistal (PD) axis is necessary for generation of the correctly patterned three-dimensional adult wing and suggests a paradigm of repression of the Hh response by N and/or Wnt signalling that may be applicable to signal integration in vertebrate appendages.
Wing vein patterning in Drosophila and the analysis of intercellular signaling.
  • S. Blair
  • Biology
    Annual review of cell and developmental biology
  • 2007
TLDR
The basic events of vein patterning are reviewed and examples of how changes in venation have been used to identify important features of cell signaling pathways are given.
Drawing lines in the Drosophila wing: initiation of wing vein development.
  • E. Bier
  • Biology
    Current opinion in genetics & development
  • 2000
Connecting Hh, Dpp and EGF signalling in patterning of the Drosophila wing; the pivotal role of collier/knot in the AP organiser.
TLDR
It is found that col mutant wings are smaller than wild type and lack L4 vein, in addition to missing the L3-L4 intervein and mis-positioning of the anterior L3 vein, and is linked to col requirement for the local upregulation of both emc and N, two genes involved in the control of cell proliferation.
Microarray Comparison of Anterior and Posterior Drosophila Wing Imaginal Disc Cells Identifies Novel Wing Genes
TLDR
Investigations of the processes downstream of en are extended by using expression array analysis to compare A and P cells and revealed that each is essential to wing development.
Hedgehog signaling and the axial patterning of Drosophila wings.
  • W. Brook
  • Biology
    Biochemistry and cell biology = Biochimie et biologie cellulaire
  • 2000
Growth and cell fate in the anterior-posterior (A/P) axis of the developing wing of Drosophila melanogaster are controlled by a stripe of cells bisecting the axis called the A/P organizer. Hedgehog
...
1
2
3
4
...