Role of killer immunoglobulin-like receptor-ligand interactions in human leukocyte antigen-matched sibling hematopoietic stem cell transplantation.

@article{Kanga2012RoleOK,
  title={Role of killer immunoglobulin-like receptor-ligand interactions in human leukocyte antigen-matched sibling hematopoietic stem cell transplantation.},
  author={Uma Kanga and Monika Mourya and Tulika Seth and Josephine George and Puneet Sood and Ravi Sharma and Aditya Saxena and Narinder K Mehra},
  journal={Transplantation proceedings},
  year={2012},
  volume={44 4},
  pages={
          919-21
        }
}
  • Uma Kanga, Monika Mourya, +5 authors Narinder K Mehra
  • Published in Transplantation proceedings 2012
  • Biology, Medicine
  • INTRODUCTION Killer immunoglobulin-like receptor (KIR)-ligand mismatches lead to natural killer cell alloreactivity after hematopoietic stem cell transplantation (HSCT). However, their clinical impact on HSCT outcomes is controversial due to complexity of KIR haplotypes, genotypes, and phenotypes as well as their diversity among patient populations. The present study investigated the role of KIR-ligand interactions in human leukocyte antigen (HLA)-matched sibling transplants. METHODS The… CONTINUE READING

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