Role of keratan sulphate (sulphated poly -N-acetyllactosamine repeats) in keratoconic cornea, histochemical, and ultrastructural analysis

@article{Akhtar2010RoleOK,
  title={Role of keratan sulphate (sulphated poly -N-acetyllactosamine repeats) in keratoconic cornea, histochemical, and ultrastructural analysis},
  author={S. Akhtar and A. J. Bron and A. Hayes and K. Meek and B. Caterson},
  journal={Graefe's Archive for Clinical and Experimental Ophthalmology},
  year={2010},
  volume={249},
  pages={413-420}
}
AimsKeratan sulphate (KS) is the predominant glycosaminoglycan (GAG) present in the corneal stroma where it is thought to regulate collagen fibril diameter. In this study we investigated the distribution of KS in normal and keratoconic corneas.MethodsFour normal, one mild, and four severe keratoconic corneas were used for the study. Distribution of keratan sulphate proteoglycans (KS-PG) was investigated using a primary monoclonal antibody (5-D-4) that recognizes disulphated disaccharides in the… Expand
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