Role of kainate receptors in nociception

@article{Ruscheweyh2002RoleOK,
  title={Role of kainate receptors in nociception},
  author={Ruth Ruscheweyh and J{\"u}rgen Sandk{\"u}hler},
  journal={Brain Research Reviews},
  year={2002},
  volume={40},
  pages={215-222}
}
Nociceptive nerve fibers use L-glutamate as a fast excitatory neurotransmitter and it is therefore not surprising that both, ionotropic and metabotropic glutamate receptors play pivotal roles for transmission of nociceptive information in spinal cord. A subtype of ionotropic glutamate receptors, the kainate receptor, is present in spinal dorsal horn. However, its role has remained obscure as specific antagonists and agonists have become available only recently. Kainate receptors are present on… CONTINUE READING

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