Role of iodine in antioxidant defence in thyroid and breast disease

@article{Smyth2003RoleOI,
  title={Role of iodine in antioxidant defence in thyroid and breast disease},
  author={P. Smyth},
  journal={BioFactors},
  year={2003},
  volume={19}
}
  • P. Smyth
  • Published 2003
  • Chemistry, Medicine
  • BioFactors
The role played in thyroid hormonogenesis by iodide oxidation to iodine (organification) is well established. Iodine deficiency may produce conditions of oxidative stress with high TSH producing a level of H2O2, which because of lack of iodide is not being used to form thyroid hormones. The cytotoxic actions of excess iodide in thyroid cells may depend on the formation of free radicals and can be attributed to both necrotic and apoptotic mechanisms with necrosis predominating in goiter… Expand
95 Citations

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