Role of intrinsic DNA binding specificity in defining target genes of the mammalian transcription factor PDX1.

@article{Liberzon2004RoleOI,
  title={Role of intrinsic DNA binding specificity in defining target genes of the mammalian transcription factor PDX1.},
  author={Arthur Liberzon and Gabriela Ridner and Michael D. Walker},
  journal={Nucleic acids research},
  year={2004},
  volume={32 1},
  pages={54-64}
}
PDX1 is a homeodomain transcription factor essential for pancreatic development and mature beta cell function. Homeodomain proteins typically recognize short TAAT DNA motifs in vitro: this binding displays paradoxically low specificity and affinity, given the extremely high specificity of action of these proteins in vivo. To better understand how PDX1 selects target genes in vivo, we have examined the interaction of PDX1 with natural and artificial binding sites. Comparison of PDX1 binding… CONTINUE READING
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