Role of intracellular glutathione in cell sensitivity to the apoptosis induced by tumor necrosis factor {alpha}-related apoptosis-inducing ligand/anticancer drug combinations.

@article{Meurette2005RoleOI,
  title={Role of intracellular glutathione in cell sensitivity to the apoptosis induced by tumor necrosis factor \{alpha\}-related apoptosis-inducing ligand/anticancer drug combinations.},
  author={Olivier Meurette and Luz Lefeuvre-Orfila and Am{\'e}lie R{\'e}billard and Dominique Lagadic‐Gossmann and Marie-Th{\'e}r{\`e}se Dimanche-Boitrel},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2005},
  volume={11 8},
  pages={
          3075-83
        }
}
  • Olivier Meurette, Luz Lefeuvre-Orfila, +2 authors Marie-Thérèse Dimanche-Boitrel
  • Published in
    Clinical cancer research : an…
    2005
  • Biology, Medicine
  • PURPOSE We have recently shown that combination of tumor necrosis factor alpha-related apoptosis-inducing ligand (TRAIL) with anticancer drugs induced an apoptotic cell death pathway involving both caspases and mitochondria. The present work further explores the role of intracellular reduced glutathione (GSH) level in cell sensitivity to this cell death pathway. EXPERIMENTAL DESIGN Intracellular GSH level was measured by high-performance liquid chromatography. Cell death was detected by… CONTINUE READING

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