Role of intracellular calcium mobilization and cell-density-dependent signaling in oxidative-stress-induced cytotoxicity in HaCaT keratinocytes.

@article{Bakondi2003RoleOI,
  title={Role of intracellular calcium mobilization and cell-density-dependent signaling in oxidative-stress-induced cytotoxicity in HaCaT keratinocytes.},
  author={Edina Bakondi and M{\'o}nika G{\"o}nczi and Eva Szab{\'o} and P{\'e}ter Bai and P{\'a}l Pacher and P{\'a}l Gergely and L. A. Kovacs and J{\'a}nos Hunyadi and Csaba Szab{\'o} and L{\'a}szl{\'o} Csernoch and L{\'a}szl{\'o} Vir{\'a}g},
  journal={The Journal of investigative dermatology},
  year={2003},
  volume={121 1},
  pages={88-95}
}
Peroxynitrite is a nitric-oxide-derived cytotoxic mediator produced in a broad range of inflammatory conditions, ranging from sunburn erythema to contact hypersensitivity. Our previous work has shown that in HaCaT cells the cytotoxic activity of peroxynitrite involves both apoptotic and necrotic routes with poly(ADP-ribose) polymerase activation serving as a mol-ecular switch diverting the default apoptotic pathway toward necrosis. Nonetheless, keratinocytes are regarded as highly resistant… CONTINUE READING
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