Role of intracellular calcium in the transient outward current of calf Purkinje fibres

@article{Siegelbaum1977RoleOI,
  title={Role of intracellular calcium in the transient outward current of calf Purkinje fibres},
  author={S P Siegelbaum and R. W. Tsien and Robert Kass},
  journal={Nature},
  year={1977},
  volume={269},
  pages={611-613}
}
CALCIUM-activated currents are known in red blood cells1, invertebrate neurones2, vertebrate spinal motoneurones3 and skate electroreceptors4, and it has been suggested that intracellular calcium increases outward currents in cardiac muscle5–7. The possibility of calcium-activated currents in heart and other muscle8,9 is interesting because these cells have intracellular stores that release calcium. Some of the apparent complexity of membrane currents in muscle might be explained as a… CONTINUE READING

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