Role of intracellular Ca2+ in EDRF release in rat aorta.

  title={Role of intracellular Ca2+ in EDRF release in rat aorta.},
  author={Xiao Feng Zheng and Chiu-yin Kwan and Edwin E. Daniel},
  journal={Journal of vascular research},
  volume={31 1},
In rings of rat aorta, cyclopiazonic acid (CPA), a selective inhibitor of the internal membrane Ca(2+)-pump ATPase, gradually initiated a concentration-dependent contraction which was much less in endothelium-intact than in endothelium-denuded rings. In phenylephrine-precontracted rings with intact endothelium, CPA, like acetylcholine, produced endothelium-dependent relaxations in a concentration-dependent manner. These were nearly abolished by methylene blue (MB) or NG-nitro-L-arginine… CONTINUE READING


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