Role of intestinal bacterial overgrowth in ethanol production and metabolism in rats.

@article{Baraona1986RoleOI,
  title={Role of intestinal bacterial overgrowth in ethanol production and metabolism in rats.},
  author={Enrique Baraona and Risto J. K. Julkunen and Libby Tannenbaum and Charles S. Lieber},
  journal={Gastroenterology},
  year={1986},
  volume={90 1},
  pages={103-10}
}
To investigate the role of intestinal bacterial overgrowth on the production and metabolism of ethanol, rats with a jejunal self-filling diverticulum (blind-loop) were compared to controls with a self-emptying diverticulum. Both endogenous ethanol and acetaldehyde were found in the blind-loop contents. Intragastric administration of sucrose produced a marked increase in acetaldehyde and acetate in the portal venous blood, with only a modest elevation of ethanol. Blind-loop contents readily… CONTINUE READING

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