Role of internalization in the pathogenicity of Shiga toxin-producing Escherichia coli infection in a gnotobiotic murine model.

@article{Aiba2002RoleOI,
  title={Role of internalization in the pathogenicity of Shiga toxin-producing Escherichia coli infection in a gnotobiotic murine model.},
  author={Yuji Aiba and Hiroki Ishikawa and Keiko Shimizu and Satoshi Noda and Yukie Kitada and Masafumi Sasaki and Y Fujioka Koga},
  journal={Microbiology and immunology},
  year={2002},
  volume={46 11},
  pages={723-31}
}
We investigated the role of bacterial internalization in the killing caused by Shiga toxin-producing Escherichia coli (STEC) infection using a gnotobiotic murine model. A high number of internalized STEC was found in the colonic epithelial cells of STEC-infected mice by both an ex vivo assay and transmission electron microscopy. Most of these mice were killed within 10 days after infection. However, the implantation of lactic acid bacteria in such mice before infection markedly decreased the… CONTINUE READING