Role of interleukin 6 in myocardial dysfunction of meningococcal septic shock

  title={Role of interleukin 6 in myocardial dysfunction of meningococcal septic shock},
  author={Nazima Pathan and Cheryl A. Hemingway and Ash A. Alizadeh and Alick C. Stephens and Jennifer C. Boldrick and Emmanuelle E Oragui and Colm McCabe and Steven B. Welch and Adeline R. Whitney and Peter O'Gara and Simon Nadel and David A. Relman and Sian E Harding and Michael Levin},
  journal={The Lancet},
BACKGROUND Myocardial failure has a central role in the complex pathophysiology of septic shock and contributes to organ failure and death. During the sepsis-induced inflammatory process, specific factors are released that depress myocardial contractile function. We aimed to identify these mediators of myocardial depression in meningococcal septic shock. METHODS We combined gene-expression profiling with protein and cellular methods to identify a serum factor causing cardiac dysfunction in… CONTINUE READING
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