Role of interleukin-6 in fibrinolytic changes induced by lipopolysaccharide in mice.

@article{Inoue2006RoleOI,
  title={Role of interleukin-6 in fibrinolytic changes induced by lipopolysaccharide in mice.},
  author={Ken-ichiro Inoue and Hirohisa Takano and Rie Yanagisawa and Miho Sakurai and Akinori Shimada and Masahiko Sato and Shin Yoshino and Toshikazu Yoshikawa},
  journal={Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis},
  year={2006},
  volume={17 4},
  pages={307-9}
}
We have recently demonstrated that interleukin (IL)-6 is protective against coagulatory and hemostatic disturbance and subsequent pulmonary hemorrhage induced by bacterial endotoxin, at least partly, via the inhibition of proinflammatory cytokines and chemokines using IL-6-null [IL-6(-/-)] mice and corresponding wild-type mice. Its role in fibrinolytic systems remains undefined, however. The present study elucidated the role of IL-6 in the activity of alpha(2)-plasmin inhibitor, an inhibitor of… CONTINUE READING
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