Role of interleukin-4 in human immunoglobulin E formation in hu-PBL-SCID mice.

  title={Role of interleukin-4 in human immunoglobulin E formation in hu-PBL-SCID mice.},
  author={Hans L. Spiegelberg and Lucinda Beck and Hans Peter Kocher and William C. Fanslow and Alexander H. Lucas},
  journal={The Journal of clinical investigation},
  volume={93 2},
We studied the role of IL-4 in human IgE formation in severe combined immunodeficient mice engrafted with peripheral blood mononuclear leukocytes (hu-PBL-SCID). PBL from four nonatopic donors produced only small (< 20 ng/ml) or undetectable amounts of IgE in SCID mice whereas engrafted PBL from seven atopic donors secreted IgE with IgE serum levels reaching a mean +/- SE of 184 +/- 37 ng/ml (n = 20). Serum IgE levels peaked 2-3 wk after PBL transfer and declined thereafter with a half-life of 1… CONTINUE READING
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Identification ofdistinct low affinity receptor for human interleukin - 4 on pre - B cells

B. G. Fishkin, F. J. Glassy, P. G. Hattersley, F. M. Hirose, H. L. Spiegelberg

Regulation of human IgE production by peripheral blood mononuclear cells from atopic patients in mice with severe combined immunodeficiency

G. C. Bosma, M. Fried, +3 authors M. J. Bosma
Int . Arch . Allergy Immunol . • 1992

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