Role of interleukin-4 in human immunoglobulin E formation in hu-PBL-SCID mice.

Abstract

We studied the role of IL-4 in human IgE formation in severe combined immunodeficient mice engrafted with peripheral blood mononuclear leukocytes (hu-PBL-SCID). PBL from four nonatopic donors produced only small (< 20 ng/ml) or undetectable amounts of IgE in SCID mice whereas engrafted PBL from seven atopic donors secreted IgE with IgE serum levels reaching… (More)

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@article{Spiegelberg1994RoleOI, title={Role of interleukin-4 in human immunoglobulin E formation in hu-PBL-SCID mice.}, author={Hans L. Spiegelberg and L. Beck and Hans Peter Kocher and William C. Fanslow and Antoine Lucas}, journal={The Journal of clinical investigation}, year={1994}, volume={93 2}, pages={711-7} }