Role of interleukin 23 signaling in Clostridium difficile colitis.

  title={Role of interleukin 23 signaling in Clostridium difficile colitis.},
  author={Erica L. Buonomo and Rajat Madan and Patcharin Pramoonjago and Li Li and Mark Douglas Okusa and William A Petri},
  journal={The Journal of infectious diseases},
  volume={208 6},
Clostridium difficile is currently the leading cause of hospital-acquired infections in the United States. Here, we observed increased interleukin 23 (IL-23) protein levels in human colon biopsy specimens positive for C. difficile toxins, compared with levels in negative controls (P = .008) We also investigated the role of IL-23 during C. difficile infection, using 2 distinct murine models. Mice lacking IL-23 signaling had a significant increase in survival (100% [12 mice]), compared with… CONTINUE READING
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