Role of interleukin-2 and interferon-gamma in inducing production of IgG subclasses in lymphocytes of human newborns.

@article{Kawano1996RoleOI,
  title={Role of interleukin-2 and interferon-gamma in inducing production of IgG subclasses in lymphocytes of human newborns.},
  author={Yutaka Kawano and Takeshi Noma},
  journal={Immunology},
  year={1996},
  volume={88 1},
  pages={40-8}
}
Unlike lymphocytes from adults, lymphocytes from cord blood of neonates cannot synthesize immunoglobulin G (IgG) in response to pokeweed mitogen (PWM). By using this mitogen in concert with interferon-gamma (IFN-gamma), interleukin-2 (IL-2), or interleukin-6 (IL-6), we studied the induction of IgG subclass molecules in lymphocytes of human neonates. IFN… CONTINUE READING