Role of interleukin-18 in acute graft-vs-host disease.

  title={Role of interleukin-18 in acute graft-vs-host disease.},
  author={Pavan Reddy and James L. M. Ferrara},
  journal={The Journal of laboratory and clinical medicine},
  volume={141 6},
Allogeneic hematopoietic cell transplantation (HCT) has emerged as an important therapeutic option for several malignant and nonmalignant diseases. In addition to delivering systemic chemoradiotherapy, the therapeutic potential of allogeneic HCT relies on the graft-vs-leukemia (GVL) effect, which eradicates residual malignant cells by way of immunologic mechanisms. Unfortunately, GVL effects are closely associated with graft-vs-host disease (GVHD), the major complication of allogeneic HCT… CONTINUE READING


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