Role of interleukin-17A in cell-mediated protection against Staphylococcus aureus infection in mice immunized with the fibrinogen-binding domain of clumping factor A.

@article{Narita2010RoleOI,
  title={Role of interleukin-17A in cell-mediated protection against Staphylococcus aureus infection in mice immunized with the fibrinogen-binding domain of clumping factor A.},
  author={Kouji Narita and Dong-Liang Hu and Fumiaki Mori and Koichi Wakabayashi and Yoichiro Iwakura and Akio Nakane},
  journal={Infection and immunity},
  year={2010},
  volume={78 10},
  pages={
          4234-42
        }
}
Clumping factor A (ClfA) is a fibrinogen-binding cell wall-attached protein and an important virulence factor of Staphylococcus aureus. Previous studies reported that an immunization with the fibrinogen-binding domain of ClfA (ClfA(40-559)) protected animals against S. aureus infection. It was reported that some cytokines are involved in the pathogenesis of staphylococcal diseases and in host defense against S. aureus infection. However, the role of cytokines in the protective effect of ClfA(40… CONTINUE READING

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Preclinical Efficacy of Clumping Factor A in Prevention of Staphylococcus aureus Infection

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