Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus.

@article{Clerici1994RoleOI,
  title={Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus.},
  author={Mario Clerici and Thomas A. Wynn and Jay A Berzofsky and Stephen P. Blatt and Craig W Hendrix and Alan Sher and Robert Lee Coffman and Gene M. Shearer},
  journal={The Journal of clinical investigation},
  year={1994},
  volume={93 2},
  pages={768-75}
}
The loss of T helper cell (TH) function in asymptomatic HIV type 1-infected individuals occurs before the decline in CD4+ T cells. At least part of the loss in TH function results from changes in immunoregulatory cytokine profiles. To investigate the role of IL-10 in such dysregulation, we tested whether: (a) expression of IL-10-specific mRNA would be upregulated in PBMC from asymptomatic, HIV-infected (HIV+) individuals; (b) PBMC from these same individuals would produce increased levels of IL… CONTINUE READING