Role of interleukin 1 in the regulation of cyclooxygenase gene expression in rat endometrial stromal cells.

@article{Bany1999RoleOI,
  title={Role of interleukin 1 in the regulation of cyclooxygenase gene expression in rat endometrial stromal cells.},
  author={Brent M. Bany and Thomas G. Kennedy},
  journal={Journal of reproduction and fertility},
  year={1999},
  volume={115 1},
  pages={
          125-31
        }
}
  • B. Bany, T. Kennedy
  • Published 1999
  • Biology, Medicine
  • Journal of reproduction and fertility
Interleukin 1 alpha (IL-1 alpha) stimulates prostaglandin production and cyclooxygenase activity in endometrial stromal cells isolated from the uteri of ovariectomized rats that have been sensitized for the decidual cell reaction. The aim of the present study was to examine the effect of IL-1 alpha on the amount of cyclooxygenase mRNA and protein in these cells. Treatment with IL-1 alpha (20 ng ml-1) for 24 h significantly increased steady-state concentrations of cyclooxygenase 2 (COX-2) mRNA… 
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Interleukin 1β-induced synthesis and secretion of prostaglandin E₂ in the porcine uterus during various periods of pregnancy and the estrous cycle.
TLDR
It is demonstrated that IL-1β activates expression of mPGES-1 mRNA in uterine tissues to stimulate synthesis and secretion of PGE₂ on days 10 to 13 of both pregnancy and the estrous cycle, which provides new insight on the role of IL- 1β in PGE ₂ production to overcome luteolysis in pregnant pigs.
Effects of epidermal growth factor, interleukin 1 and nitric oxide on prostaglandin production by guinea-pig uterus.
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The findings indicate that EGF and nitric oxide may act as mediators in the mechanism by which oestradiol acting on a progesterone-primed uterus stimulates the increase in PGF(2alpha) production by the guinea-pig uterus necessary for luteolysis.
Treatment with prostaglandin F2alpha increases expression of prostaglandin synthase-2 in the rat corpus luteum.
Role of leukemia inhibitor factor (LIF) in decidualisation of murine uterine stromal cells in vitro.
TLDR
It is shown that LIF suppresses decidualisation of murine uterine stromal cells in the presence of serum, this is not due to the regulation of PGE(2) secretion by stroma cells.
The effect of tumor necrosis factor α (TNFα), interleukin 1β (IL1β) and interleukin 6 (IL6) on endometrial PGF2α synthesis, metabolism and release in early-pregnant pigs.
Leukemia Inhibitory Factor ( LIF ) and is aberrant 1 in Lif-/-mouse uterus 1 2
TLDR
The regulation of the Interleukin 1 (IL1) system in the murine uterine 16 luminal epithelium and stroma by leukemia inhibitory factor (LIF) is addressed and it is concluded that Il1a and Il1rn in LE andIl1a, Il1r1 and Il 1r1 in 30 stroma are regulated by LIF which stimulates apical secretion of IL1A by LE.
Interleukin 1 Signaling Is Regulated by Leukemia Inhibitory Factor (LIF) and Is Aberrant in Lif−/− Mouse Uterus1
TLDR
Le-stromal coculture revealed that LIF stimulated the apical secretion of both IL1A and PTGES2 by LE cells without affecting basal secretion of IL 1A and with only a small effect on basalPTGES2 secretion.
Biochemistry of Cyclooxygenase (COX)-2 Inhibitors and Molecular Pathology of COX-2 in Neoplasia
  • E. Fosslien
  • Biology, Medicine
    Critical reviews in clinical laboratory sciences
  • 2000
TLDR
Findings might somewhat limit the use of presently available selective COX-2 inhibitors in cancer prevention but will probably not deter their successful application for the treatment of human cancers.
Sphingosine-1-Phosphate Receptor Expression and Signaling Correlate with Uterine Prostaglandin-Endoperoxide Synthase 2 Expression and Angiogenesis During Early Pregnancy1
TLDR
The existence of a link between the sphingolipid and prostanoid signaling pathways in uterine physiology is suggested and it is suggested that S1P receptors function to coordinate uterine mesometrial angiogenesis during the implantation phase of early gestation.
Peroxisome-proliferator-activated receptors and the control of levels of prostaglandin-endoperoxide synthase 2 by arachidonic acid in the bovine uterus.
TLDR
The results are consistent with the hypothesis that arachidonic acid acts via PPARalpha to increase PTGS2 levels in bovine endometrial stromal cells.
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The results of this study suggest that epidermal growth factor causes an increase in cyclooxygenase-1 and cycling enzyme gene expression in endometrial stromal cells isolated from the uteri of rats which have been sensitized for decidualization.
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