Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade

@article{Pascual2005RoleOI,
  title={Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade},
  author={Virginia Pascual and Florence Allantaz and Edsel Arce and Marilynn G. Punaro and Jacques Banchereau},
  journal={The Journal of Experimental Medicine},
  year={2005},
  volume={201},
  pages={1479 - 1486}
}
Systemic onset juvenile idiopathic arthritis (SoJIA) encompasses approximately 10% of cases of arthritis that begin in childhood. The disease is unique in terms of clinical manifestations, severity of joint involvement, and lack of response to tumor necrosis factor blockade. Here, we show that serum from SoJIA patients induces the transcription of innate immunity genes, including interleukin (IL)-1 in healthy peripheral blood mononuclear cells (PBMCs). Upon activation, SoJIA PBMCs release large… CONTINUE READING
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