Role of interleukin‐6 in stress, sleep, and fatigue

@article{Rohleder2012RoleOI,
  title={Role of interleukin‐6 in stress, sleep, and fatigue},
  author={Nicolas Rohleder and Martin Aringer and Matthias Boentert},
  journal={Annals of the New York Academy of Sciences},
  year={2012},
  volume={1261}
}
Chronic low‐grade inflammation, in particular increased concentrations of proinflammatory cytokines such as interleukin (IL)‐6 in the circulation, is observed with increasing age, but it is also as a consequence of various medical and psychological conditions, as well as life‐style choices. Since molecules such as IL‐6 have pleiotropic effects, consequences are wide ranging. This short review summarizes the evidence showing how IL‐6 elevations in the context of inflammatory disease affect the… Expand
Sleep Loss as a Factor to Induce Cellular and Molecular Inflammatory Variations
TLDR
The aim of this review is to integrate data from recent published reports on the effects of sleep loss on the immune response to allow readers to have an integrated view of the mechanisms involved in central and peripheral deficits induced by sleep loss. Expand
[Sleep and immune system].
TLDR
Sleep emerges as an important regulator of the immune system since, during sleep, the necessary functions to maintain its balance are carried out, and decreased sleep has deleterious effects that alter the metabolism and produce an increase in the secretion of C-reactive protein, interleukin (IL)-6 and tumor necrosis factor (TNF). Expand
Interleukin-6 as potential mediator of long-term neuropsychiatric symptoms of COVID-19
TLDR
It is proposed that neuroimmune cross-talk via inflammatory cytokines such as interleukin-6 (IL-6) could underpin these long-term COVID-19 symptoms, and that targeting IL-6 pathways could be helpful for treatment and prevention of long COVID are important questions that require investigation. Expand
Biological Interaction of Stress and Osteoporosis
TLDR
Understanding these conditions will be helpful in discovering the effective prevention and treatment of osteoporosis, therefore this review will focus on the biological interaction between stress and bone health. Expand
Salivary Inflammatory Molecules as Biomarkers of Sleep Alterations: A Scoping Review
TLDR
An analysis of the current evidence related to changes in inflammatory markers in the saliva and their associations with sleep quality measurement (both objective and subjective methods) in healthy subjects and in sleep-related disorders shows the relationship between these salivary biomarkers and sleep quality. Expand
Coping with stress, control of emotions and biochemical markers as a common protective element in the inflammatory response to stress.
TLDR
In difficult situations, accompanied by an increase in the variables responsible for the biochemical inflammatory response of an organism, the effective model of coping with difficult situations and emotioncontrol increases, while the subjective level of perceived stress drops. Expand
Neuroendocrine and neurophysiological effects of interleukin 6 in rheumatoid arthritis
TLDR
Current understanding of emerging aspects of IL-6 in RA-associated pain, fatigue and mood disorders such as depression and anxiety are discussed and the clinical effects ofIL-6 inhibition on these symptoms and co-morbidities in patients with RA are described. Expand
Role of Interleukin-6 in Depressive Disorder
TLDR
The important role of neuroinflammation in MDD pathogenesis has created a new perspective that the combining of blood IL-6 and other depression-related cytokine levels may help to classify MDD biological subtypes, which may allow physicians to identify the optimal treatment for MDD patients. Expand
Exogenous Interleukin-10 and ciprofloxacin treatment reduces inflammation and helps to improve cognitive behaviour in acute and chronic restraint stressed mice infected with Escherichia coli
TLDR
This study suggests an alternative therapeutic modality where impaired glucocorticoid sensitivity interferes with the appropriate regulation of inflammation, and suggests IL-10 and CIP treated animals also showed improved exploration and locomotion in OFT and EPM. Expand
Sleep quality and cytokine expression after an exhaustive exercise: influence of ACE polymorphism I/D
TLDR
The increase of IL-10 observed in I/I and I/D genotypes could play a protective role on sleep, and the ACE D/ D genotype seems to be more exposed to sleep disturbance after exercise. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 118 REFERENCES
Humoral Links between Sleep and the Immune System
TLDR
It is reached the tentative conclusion that the sleep‐promoting actions of IL‐1 and GHRH are mediated via anterior hypothalamic neurons that are receptive to these substances, and it seems likely that TNF‐α and CRH also influence these neurons. Expand
Sleep enhances IL‐6 trans‐signaling in humans
  • S. Dimitrov, T. Lange, +5 authors J. Born
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2006
TLDR
The selective increase in sIL‐6R implicates an enhanced trans‐signaling capacity whereby sleep distinctly widens the profile of IL‐6 actions, enabling an integrated influence on brain and peripheral organs. Expand
Interleukin‐6: A Cytokine for Gerontolgists
  • W. Ershler
  • Medicine
  • Journal of the American Geriatrics Society
  • 1993
TLDR
The biology of this important cytokine is presented and its relevance to gerontology is highlighted and it is proposed that this reflects an age‐associated loss in the normal regulation of gene expression for this molecule. Expand
Chronic stress and age-related increases in the proinflammatory cytokine IL-6
TLDR
Evidence is provided of a key mechanism through which chronic stressors may accelerate risk of a host of age-related diseases by prematurely aging the immune response. Expand
The effects of acute psychological stress on circulating inflammatory factors in humans: A review and meta-analysis
TLDR
The purpose of this review is to synthesize existing data using meta-analytic techniques and show robust effects for increased levels of circulating IL-6 and IL-1beta following acute stress, and marginal effects for CRP after acute stress. Expand
IL-6 and Its Circadian Secretion in Humans
TLDR
IL-6 is a mediator of sleepiness and its circadian pattern reflects the homeostatic drive for sleep, and appears to be somnogenic in rats. Expand
Acute effects of recombinant human interleukin-6 on endocrine and central nervous sleep functions in healthy men.
TLDR
The results underscore the importance of IL-6 in the cascade of cytokines for the neuroendocrine response during the acute phase reaction and appear to be involved in changes of sleep and behavior accompanying infection and inflammatory disorders. Expand
Exposure to physical and psychological stressors elevates plasma interleukin 6: relationship to the activation of hypothalamic-pituitary-adrenal axis.
TLDR
It is confirmed by showing that rats exposed to electric footshock, physical restraint, or a conditioned aversive stimulus have increased levels of plasma IL-6, and the kinetics of the increase resembled that of increase in plasma corticosterone, which suggests that increased plasmaIL-6 may be part of the hormonal responses to stress. Expand
Socioeconomic status and stress-induced increases in interleukin-6
TLDR
It is suggested that low SES people are less able to adapt to stress than their high SES counterparts, and prolonged stress-induced increases in IL-6 in low S ES groups represents a novel mechanism potentially linking socioeconomic position and heart disease. Expand
Life stress, mood disturbance, and elevated interleukin-6 in healthy older women.
TLDR
Levels of IL-6 in three groups of healthy older women with varying levels of life stress and mood disturbance and a healthy group of young women suggest that in older women, chronic stressors are associated with significant elevations in IL- 6 over and above the elevations associated with normal aging, but that moderate stressors may not be related to appreciable elevations. Expand
...
1
2
3
4
5
...