Role of interferon-gamma in mediating the antitumor efficacy of interleukin-12.

@article{Brunda1995RoleOI,
  title={Role of interferon-gamma in mediating the antitumor efficacy of interleukin-12.},
  author={Michael J. Brunda and Leopoldo Luistro and Jill A. Hendrzak and Michael Fountoulakis and Gianni Garotta and Maurice K. Gately},
  journal={Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy},
  year={1995},
  volume={17 2},
  pages={
          71-7
        }
}
Although interleukin-12 (IL-12) has marked antitumor activity against the murine Renca renal cell carcinoma in vivo, no antiproliferative activity with IL-12 was observed against these tumor cells in vitro; in contrast, interferon-gamma (IFN-gamma) had growth inhibitory activity. Since one of the properties of IL-12 is its ability to stimulate production of IFN-gamma, the role of IFN-gamma in mediating the antitumor activity of IL-12 was evaluated. Substantially diminished antitumor activity… CONTINUE READING

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