Role of interferon alpha in promoting T helper cell type 1 responses in the small intestine in coeliac disease.

  title={Role of interferon alpha in promoting T helper cell type 1 responses in the small intestine in coeliac disease.},
  author={Giovanni Monteleone and Sylvia L. F. Pender and Elspeth M Alstead and A Christina Hauer and Paolo Lionetti and Carroll McKenzie and Thomas Macdonald},
  volume={48 3},
Coeliac disease (CD) is caused by a CD4 T helper cell type 1 (Th1) response in the small intestinal mucosa to dietary gluten. As the major Th1 inducing cytokine, interleukin 12, is undetectable in CD gut mucosa, the mechanism by which Th1 effector cells are generated remains unknown. Interferon (IFN) alpha, a cytokine capable of promoting IFN-gamma synthesis, has been implicated in the development of Th1 mediated immune diseases. Here we report a case of CD-like enteropathy in a patient… CONTINUE READING


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