Role of integrins in endothelial mechanosensing of shear stress.

@article{Shyy2002RoleOI,
  title={Role of integrins in endothelial mechanosensing of shear stress.},
  author={John Y. -J. Shyy and S H-L Chien},
  journal={Circulation research},
  year={2002},
  volume={91 9},
  pages={
          769-75
        }
}
The focal pattern of atherosclerotic lesions in arterial vessels suggests that local blood flow patterns are important factors in atherosclerosis. Although disturbed flows in the branches and curved regions are proatherogenic, laminar flows in the straight parts are atheroprotective. Results from in vitro studies on cultured vascular endothelial cells with the use of flow channels suggest that integrins and the associated RhoA small GTPase play important roles in the mechanotransduction… CONTINUE READING

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