Role of integrins and evidence for two distinct mechanisms mediating human colorectal carcinoma cell interaction with peritoneal mesothelial cells and extracellular matrix.

@article{Schlaeppi1997RoleOI,
  title={Role of integrins and evidence for two distinct mechanisms mediating human colorectal carcinoma cell interaction with peritoneal mesothelial cells and extracellular matrix.},
  author={M Schlaeppi and Curzio R{\"u}egg and C. Tr{\^a}n-Thang and Germain Chapuis and Hendrik Tevaearai and Harald Lahm and Bernard Sordat},
  journal={Cell adhesion and communication},
  year={1997},
  volume={4 6},
  pages={439-55}
}
Peritoneal carcinomatosis involves a series of events including tumor cell interactions with mesothelial cells and the extracellular matrix (ECM). We have studied the adhesive and invasive properties of four human colorectal carcinoma cell lines (Co115, HT29, SW480, SW620) confronted in vitro with a human mesothelial cell monolayer or with the ECM proteins collagen IV, laminin-1, fibronectin, tenascin-C and vitronectin. Quantitation was achieved following staining of tumor cells with the… CONTINUE READING

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